Research Paper Volume 15, Issue 22 pp 13010—13040
Identification of topoisomerase 2A as a novel bone metastasis-related gene in liver hepatocellular carcinoma
Figure 1. TOP2A is associated with bone metastasis of liver hepatocellular carcinoma. (A) Volcano plot of differentially expressed genes (DEGs) between LIHC and paracancerous tissues from GSE27635 database, red indicated up-regulated genes, and blue indicated down-regulated genes. (B) Volcano plot of DEGs between LIHC with BM and NBM. (C) Heatmap of DEGs between LIHC with and without BM. (D) Venn diagram of DEGs from A and B. (E) GO and KEGG enrichment analysis of the above overlapping genes. P, peritumor; T, tumor; BM, bone metastasis; NBM, non-bone metastasis.