Research Paper Volume 15, Issue 21 pp 12251—12263
Polyphyllin I attenuates the invasion and metastasis via downregulating GRP78 in drug-resistant hepatocellular carcinoma cells
Figure 6. PPI inhibits the proliferation of sorafenib-resistant cells in vivo. (A) PPI treatment inhibited tumor growth and decreased tumor sizes in mice. The tumor weight of mice treated with sorafenib-resistant HepG2 cells with or without PPI administration is represented in a bar graph as mean ± SD. The tumor volume of mice treated with sorafenib-resistant HepG2 cells with or without PPI administration is represented in a bar graph as mean ± SD. (B) HE staining of tumor tissues was performed to evaluate the effect of PPI administration. (C) IHC analysis was performed for Ki67, GRP78, N-cadherin, Vimentin, and ABCG2 on tumor tissue samples obtained during administration with or without PPI. Statistical significance is indicated by asterisks (*P < 0.05, **P < 0.01).