Polyphyllin I attenuates the invasion and metastasis via downregulating GRP78 in drug-resistant hepatocellular carcinoma cells

Haiyan Du; Haochen Wu; Qinyang Kang; Mianmian Liao; Meirong Qin; Ning Chen; Houshuang Huang; Danping Huang; Ping Wang; Guangdong Tong

doi:doi:10.18632/aging.205176

← Back

Research Paper Volume 15, Issue 21 pp 12251—12263

Polyphyllin I attenuates the invasion and metastasis via downregulating GRP78 in drug-resistant hepatocellular carcinoma cells

Figure 4. GRP78 is a key target that increases sorafenib resistance and promotes invasion and metastasis in liver cancer. (A) The effect of sorafenib on the expression of proteins in SR-HCC. The expression levels of proteins (E-cadherin, N-cadherin, Vimentin, ABCG2 and GRP78) in HCC cells treated with sorafenib for 24 h. (B) The effects of GRP78 overexpression/knockdown on protein expression in HepG/S cells. (C) Effects of GRP78 overexpression/knockdown on migration and invasion of SR-HCC cells.