Research Paper Volume 15, Issue 21 pp 12225—12250
Plumbagin has an inhibitory effect on the growth of TSCC PDX model and it enhances the anticancer efficacy of cisplatin
Figure 5. Anti-proliferative effect of plumbagin on TSCC PDX model. Ki67 IHC analysis was performed on each group of PDX models. (A) Use IHC to detect Ki67 expression. Nuclei of tumor cells were stained with hematoxylin (purple) and Ki67 positive cells have brown nuclei. (B) Quantitative analysis of Ki67 positive cells. Six 400X images were analyzed for each bar. Each bar represented the positivity cell rate, and the positivity cell rate was calculated as the ratio of the number of positive cells to the number of total cells. ***P < 0.001; −, no statistical difference.