Research Paper Volume 15, Issue 21 pp 12225—12250

Figure 3. The anti-tumor effect of plumbagin on tongue squamous cell carcinoma. (A) TSCC PDX models were established. The mice were treated with plumbagin, cisplatin and their combination as described in Methods. (B) The tumor volume and the bodyweight were recorded every three days. The animals were sacrificed after 21 days of drug treatment. Representative samples of the PDX models showing the difference in tumor sizes between control, plumbagin, cisplatin and their combination. (C) Tumor weights of the PDX models were measured at the end of the experiment. (D) Tumor volumes of the PDX models after administration of plumbagin, cisplatin and their combination. (E) Body weights of the mice after administration of plumbagin, cisplatin and their combination. ^***p < 0.001; ^**p < 0.01; ^*p < 0.05 and −, no statistical difference.