Research Paper Volume 15, Issue 21 pp 12171—12191
CENPB promotes the proliferation of hepatocellular carcinoma and is directly regulated by miR-29a
Figure 6. miR-29a may act as a suppressor for HCC by negatively regulating CENPB expression. (A) The volcano plot revealed positively correlated and negatively correlated miRNAs with CENPB expression in the LinkedOmics database. (B, C) Heatmaps illustrating the top 50 miRNAs showing positive (B) and negative (C) correlations with CENPB expression. (D) Three overlapping miRNAs: miR-29a, miR-100-3p, and miR-3144 were identified from the LinkedOmics, TargetScan, miRtarbase, and miRwalk databases. (E) The Venny diagram exhibited that miR-29a is overlapping in “3 Common miRNAs” and “CENPB Negatively Correlated Significant miRNAs (top 50)”. (F) Association of miR-29a expression with clinicopathologic outcomes in HCC patients in the LinkedOmics database. (G) miR-29a expression is decreased in in HCC tissue, with a further decrease observed in metastatic tissues. (H, I) A gradual decrease in miR-29a expression as the tumor stage (H) and pathological grade (I) increased.