Research Paper Volume 15, Issue 21 pp 12171—12191

Figure 1. Prognostic significance of CENPB mRNA in HCC. (A–C) CENPB mRNA was found to be higher in HCC compared to normal liver tissues, as observed in the TCGA (A), GSE54236 (B), and GSE76427 (C) datasets. (D) The diagnostic potential of CENPB was assessed using ROC curves in the TCGA, GSE54236, and GSE76427 datasets. (E, F) CENPB mRNA levels exhibited a gradual increase with advancing tumor stage (E) and grade (F). (G, H) Elevated CENPB mRNA levels were associated with poor OS (G) and RFS (H). (I, J) High CENPB mRNA levels were predictive of poor OS (I) and RFS (J) specifically in stage I/II patients. (K, L) High CENPB mRNA levels predicted unfavorable OS (K) and RFS (L) in grade I/II patients.