Research Paper Volume 15, Issue 21 pp 12104—12119
Collaborating single-cell and bulk RNA sequencing for comprehensive characterization of the intratumor heterogeneity and prognostic model development for bladder cancer
Figure 5. Analysis of subclassification of epithelial cells. (A) The UMAP diagram showed the 17 subclusters of the epithelial cells. (B) The UMAP diagram showed the distribution of normal and tumorous cells in the whole epithelial population. (C) The correlation heat map showing the correlative relationship between different subclusters. (D) The TF enrichment analysis results, shown in the form of heat map. (E) The UMAP diagram showing the distribution of normal, premalignant and malignant cells in the whole cell population. (F) The enrichment heat map showing the predicted activity of transcription factors in different subclusters. (G–J) The predicted activity of SP1 (G), E2F4 (H), MYC (I), SOX2 (J) in each of the subclusters, shown in the form of UMAP map. (K–M) The activity of the dominant functional pathways, including p53 (K), NFkB (L), Trail (M), in each epithelial cell subcluster.