Research Paper Volume 15, Issue 24 pp 14651—14665
The peptide Acein promotes dopamine secretion through clec-126 to extend the lifespan of elderly C. elegans
Figure 6. Mechanistic diagram of the antiaging effect of Acein in the clec-126 overexpressing C. elegans model. Acein inhibits the expression of clec-126 to increase dopamine secretion to prolong C. elegans lifespan, increase C. elegans brood number and motility, reduce motility decline, and delay C. elegans senescence. In addition, col-41 was first found to be downstream of clec-126, and clec-126 promotes col-41 expression.