The peptide Acein promotes dopamine secretion through <i>clec-126</i> to extend the lifespan of elderly <i>C. elegans</i>

Jiaqi Wang; Dong Wang; Sarra Setrerrahmane; Jean Martinez; Han-Mei Xu

doi:doi:10.18632/aging.205150

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Research Paper Volume 15, Issue 24 pp 14651—14665

The peptide Acein promotes dopamine secretion through clec-126 to extend the lifespan of elderly C. elegans

Figure 5. Interaction of clec-126 with four differentially expressed genes, T02D1.7, nspf-3, col-41 and Y34F4.3. (A) Differential expression of T02D1.7, nspf-3, col-41 and Y34F4.3 in overexpressing clec-126 C. elegans. (B–E) Correlation analysis between clec-126 and T02D1.7, nspf-3, col-41 and Y34F4.3. (F) Changes in clec-126 after RNA interference with col-41. (G) Mechanism of action of clec-126 with col-41. Compared with the control group. ^*p < 0.05, ^**p < 0.01, ^***p < 0.001, ^****p < 0.0001.