Research Paper Volume 15, Issue 24 pp 14651—14665
The peptide Acein promotes dopamine secretion through clec-126 to extend the lifespan of elderly C. elegans
Figure 3. Aging-associated phenotypic assay results in C. elegans with clec-126-RNAi. (A) qPCR validation results of clec-126-RNAi C. elegans. (B) Lifespan experiments for clec-126-RNAi C. elegans. (C) Dopamine changes in C. elegans at 48 h. (D) Changes in dopamine levels in C. elegans with age. (E) Head swing in clec-126-RNAi C. elegans. (F) Body bending in clec-126-RNAi C. elegans. (G) Detection results of pharyngeal pumping in clec-126-RNAi C. elegans. (H) Survival curve on Day 8 in clec-126-RNAi C. elegans group in a thermostressed environment at 35°C. (I) Head swing frequency in clec-126-RNAi C. elegans of different age groups. (J) Pharyngeal pumping frequency in clec-126-RNAi C. elegans of different age groups. Compared with the vehicle group, nsp > 0.05, *p < 0.05, **p < 0.01, ***p < 0.001.