Figure 5. Construction of the risk signature. (A) Multivariate Cox regression analysis. (B) LASSO regression analysis. (C) Heatmap of clinical correlations, with asterisks representing differences in this clinical trait between high- and low-risk groups. ***p < 0.001; **p < 0.01; *p < 0.05. (D) Clinical correlation analysis of differences in risk scores between different clusters. (E) Sankey diagram linking cluster, risk, and prognosis. (F) Box plot for differential analysis of IRGs in high- and low-risk groups.