Research Paper Volume 15, Issue 20 pp 11546—11553

Figure 3. Inhibition of MDM2 can antagonize ICA’s effect on AD mice. (A–E) Morris water maze (n= 10). In ASO-MDM2 and ICA+ASO-MDM2 groups, escape latency was shortened, platform crossings were increased and swimming distance was lengthened, showing significant differences from the AD group, albeit insignificant differences between these two groups. ^*P< 0.05 vs. AD. (F, G) Iron content and JC-1 (n= 10). ASO-MDM2 and ICA+ASO-MDM2 could lower the iron ion content in brain, enhance the level of JC-1 polymerization, and increase the polymer/monomer ratio. ^*P< 0.05 vs. AD. (H, I) SOD and MDA (n= 10). ASO-MDM2 and ICA+ASO-MDM2 could suppress the level of MDA and elevate the level of SOD. ^*P< 0.05 vs. AD.