Research Paper Volume 15, Issue 21 pp 11860—11874
Lipid reprogramming induced by the NNMT-ABCA1 axis enhanced membrane fluidity to promote endometrial cancer progression
Figure 4. Cholesterol efflux is improved thanks to NNMT’s ability to upregulate ABCA1. (A) Gene set enrichment analysis (GSEA) was used to investigate pathways involved in NNMT-related metabolism. (B) Expression bands of proteins involved in cholesterol metabolism. (C) Example immunohistochemical staining for NNMT and ABCA1 proteins in EC tumors (Scale: 100 μm). (D) Inhibition of cholesterol production and uptake leads to a significant drop in intracellular cholesterol levels. (*P < 0.05, **P < 0.01, NS = not significant).