Research Paper Volume 15, Issue 20 pp 11532—11545
Indoxyl sulfate induced frailty in patients with end-stage renal disease by disrupting the PGC-1α–FNDC5 axis
Figure 4. Expression of TGF-β receptor and irisin was downregulated in mice with 5/6 nephrectomy. (A, C) The expression of TGF-βR1, TGF-βR2 and TGF-βR3 in the gastrocnemius in between the sham group and the 5/6 nephrectomized mice through real-time PCR. (B) Expression of TGF-βR1, TGF-βR2 and TGF-βR3 in 5/6 nephrectomized mice with and without resveratrol (RSV) treatment through real-time PCR. (C) Expression of irisin in sham group and the 5/6 nephrectomized mice through real-time PCR. (D) Expression of irisin in the 5/6 nephrectomized mice with and without RSV treatment through real-time PCR.