Research Paper Volume 15, Issue 20 pp 11471—11488
The Wnt/β-catenin signaling pathway inhibits osteoporosis by regulating the expression of TERT: an in vivo and in vitro study
Figure 6. LiCl reverses the H2O2-induced reduction in the nuclear translocation of β-catenin and the interaction between β-catenin and TERT in BMSCs. (A) Co-IP showing β-catenin binding to TERT in BMSCs. (B) Immunofluorescence staining reveals nuclear translocation of β-catenin in BMSCs treated with H2O2 or LiCl. (C) Immunofluorescence assays were performed to identify colocalization between β-catenin and TERT in BMSCs treated with H2O2 or LiCl. All results were performed as mean ± SD. #P < 0.05 vs. control group, *P < 0.05 vs. H2O2 group, n = 6. Scale bar: 100 μm.