Research Paper Volume 15, Issue 20 pp 11369—11388

Figure 3. Construction of a prognostic risk model for PCa according to integrin αvβ3/α6β1. (A) Heatmap of differentially expressed genes (DEGs) and clinical characteristics for two clusters in the TCGA cohort. (B) Forest plot of 51 DEGs interfering with the biochemical recurrence of PCa in the TCGA cohort. (C) LASSO Cox regression analysis for eight biochemical recurrence-related genes in both the TCGA and GEO cohorts. (D) LASSO Cox regression of cross-validation between the TCGA and GEO cohorts. (E, F) Heatmaps of the expression of 8 biochemical recurrence-related genes in the TCGA and GEO cohorts. (G) qPCR was used to verify the gene expression levels of the constructed model in biochemically recurrent and nonbiochemically recurrent PCa.