Research Paper Volume 15, Issue 20 pp 11227—11243
Electroacupuncture pretreatment protects against anesthesia/surgery-induced cognitive decline by activating CREB via the ERK/MAPK pathway in the hippocampal CA1 region in aged rats
Figure 5. EA pretreatment activates the MAPK/ERK/CREB signaling pathway to exert a neuroprotective effect in rats with POCD. The expression of proteins related to the MAPK/ERK/CREB signaling pathway, including MEK (A), phosphorylated ERK/ERK (B) and phosphorylated CREB (pCREB)/CREB (C). (D) Representative immunostaining showing the colocalization of p-CREB (red) and DAPI (blue) in the CA1 of the hippocampus. Scale bar: 200 μm. Data are shown as means ± standard deviations. *p < 0.05, **p < 0.01.