Myeloid-specific knockout of SHP2 regulates PI3K/PLCγ signaling pathway to protect against early myocardial infarction injury

Menglin Sha; Hongxing Li; Bingyan Guo; Xiaoyong Geng

doi:doi:10.18632/aging.205096

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Research Paper Volume 15, Issue 18 pp 9877—9889

Myeloid-specific knockout of SHP2 regulates PI3K/PLCγ signaling pathway to protect against early myocardial infarction injury

Figure 3. SHP2^MAC-KO reduces the number of apoptosis and inflammatory cell infiltration in mouse myocardial infarction. (A) Plots of TUNEL staining results and statistics of the number of apoptotic cells; (B) immunohistochemical staining results and relative fluorescence intensity data of TNFα. **P<0.01, ns P>0.05.