Research Paper Volume 15, Issue 19 pp 10540—10548
Sonic hedgehog signaling promotes angiogenesis of endothelial progenitor cells to improve pressure ulcers healing by PI3K/AKT/eNOS signaling
Figure 2. SHH pathway enhances proliferation and migration of EPCs by PI3K/AKT/eNOS signaling. (A, B) The EPCs were treated with SAG (1 μM), cyclopamine (10 μM), Y294002 (5 μM), or co-treated with SAG (1 μM) and Y294002 (5 μM). (A) The cell migration was examined by Transwell assays. (B) The cell proliferation was determined by CCK-8 assays. N = 3. Scale bar: 20 μm.