Research Paper Volume 15, Issue 19 pp 10524—10539
Paroxetine protects against bleomycin-induced pulmonary fibrosis by blocking GRK2/Smad3 pathway
Figure 5. PRXT promoted the expression of GRK2 and Smad3 in lung tissues from bleomycin-induced mice. (A–D) Relative mRNA expression levels of Grk2, Smad3, Smad2, and Smad4 in murine lung tissues (n=5). (E–K) Representative western blotting images of GRK2, P-Smad3, Smad3, P-Smad2, Smad2, and Smad4 and their quantification in murine lung tissues (n=5). *P < 0.05 vs. the Control group, #P < 0.05 vs. the PF group. PF, pulmonary fibrosis. PRTX-H, Paroxetine-High dose (7.5 mg·kg−1·day−1).