Research Paper Volume 15, Issue 19 pp 10407—10427

Figure 7. PLCL1 suppresses RCC tumour proliferation in vivo. (A, B) Representative images of PLCL1 and PLCL1-control RCC tumour growth in Balb/c nude mice. The tumour volume (C) and weight (D) in the xenograft tumour model are shown. (E) Representative images of renal orthotopic models between PLCL1 and vector control samples. (F) Representative PET scan results of the mouse orthotopic model. (G) HE, immunohistochemistry and quantitative analyses of PLCL1, LC3B, Ki67 and Bax in mouse tumour specimens. Each group n = 5. Student’s t test was performed to determine statistical significance between two groups. Scale bar: 100 μm. ^**P < 0.01, ^***P < 0.001.