Research Paper Volume 15, Issue 19 pp 10370—10388
Bridging the gap between clear cell renal cell carcinoma and cutaneous melanoma: the role of SCARB1 in dysregulated cholesterol metabolism
Figure 2. Identification and comparison of various cholesterol metabolic subtypes of ccRCC. (A) Consensus clustering matrix for k = 2. (B) The K-M survival curve showing the poorer survival probability of ccRCC patients in cluster A (p < 0.05). (C) The heatmap showing the clinicopathological characteristics, cluster situation, and expression levels of each survival-related CMGs of ccRCC samples. (D) GO functional annotation analysis of DEGs between clusters A and B, including enriched biological processes (BP), cellular components (CC), and molecular functions (MF). (E) KEGG pathway enrichment of DEGs between clusters A and B. The enriched items were analyzed by using gene counts, gene ratio, and adjusted p values. (F) The heatmap showing the biological pathways associated with distinct cholesterol metabolic modification subtypes by GSVA enrichment analysis. (G) Consensus clustering matrix for k = 2 in the E-MTAB-1980 cohort. (H) The K-M survival curve showing the poorer survival probability of ccRCC patients in cluster 1 from the E-MTAB-1980 cohort (p < 0.05).