Senescence-associated inflammation and inhibition of adipogenesis in subcutaneous fat in Werner syndrome

Daisuke Sawada; Hisaya Kato; Hiyori Kaneko; Daisuke Kinoshita; Shinichiro Funayama; Takuya Minamizuka; Atsushi Takasaki; Katsushi Igarashi; Masaya Koshizaka; Aki Takada-Watanabe; Rito Nakamura; Kazuto Aono; Ayano Yamaguchi; Naoya Teramoto; Yukari Maeda; Tomohiro Ohno; Aiko Hayashi; Kana Ide; Shintaro Ide; Mayumi Shoji; Takumi Kitamoto; Yusuke Endo; Hideyuki Ogata; Yoshitaka Kubota; Nobuyuki Mitsukawa; Atsushi Iwama; Yasuo Ouchi; Naoya Takayama; Koji Eto; Katsunori Fujii; Tomozumi Takatani; Tadashi Shiohama; Hiromichi Hamada; Yoshiro Maezawa; Koutaro Yokote

doi:doi:10.18632/aging.205078

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Research Paper Volume 15, Issue 19 pp 9948—9964

Senescence-associated inflammation and inhibition of adipogenesis in subcutaneous fat in Werner syndrome

Figure 3. Transcriptome analysis reveals distinct gene expression in WSVF. (A) k-means clustering of HSVF and WSVF. (B) List of the top ten gene ontology terms and corresponding p values related to Figure 3A. Pathway analysis of the top 2000 transcriptome using GO biological process. WS: Werner syndrome; SVF: stromal vascular fraction; HSVF: SVF derived from a healthy individual; WSVF: SVF derived from a patient with WS.