Research Paper Volume 15, Issue 19 pp 10305—10329
The integrated single-cell analysis developed an immunogenic cell death signature to predict lung adenocarcinoma prognosis and immunotherapy
Figure 8. Analysis of immune cell content and immune checkpoint. (A) A box plot showed that differences in immune checkpoint gene expression between high- and low-risk groups. (B) Correlation between model genes and immune checkpoint. (C) The low-risk group has significantly greater IPS, IPS-CTLA4-neg-PD-1-neg, IPS-CTLA4-pos-PD-1-neg, IPS-CTLA4-neg-PD-1-pos, and IPS-CTLA4-pos-PD-1-pos. (D) The violin plot demonstrated the difference in Stromal Score, Immune Score, ESTIMATE Score, and tumor purity calculated using the ESTIMATE algorithm between the two risk subgroups. (E) The correlations in Stromal Score, Immune Score, ESTIMATE Score, and tumor purity were calculated using the ESTIMATE algorithm between the two risk subgroups. Note: *P < 0.05, **P < 0.01, ***P < 0.001.