Research Paper Volume 15, Issue 19 pp 10168—10192

Figure 6. Functional enrichment analysis and GSEA analysis. (A) GO circle plots displayed scatter plots of log fold change (logFC) for the most statistically significant GO terms. Red dots represented up-regulated genes and blue dots represented down-regulated genes. The inner circles displayed z-scores calculated as the number of up-regulated genes minus the number of down-regulated genes divided by the square root of the count. (B–I) GSEA analysis exhibited that Biocarta NAK pathway (B), Reactome TNFs their physiological receptors (C), Reactome signaling by the B Cell receptor bcr (D), Reactome interleukin 12 signaling (E), Reactome interleukin 2 family signaling (F), KEGG toll like receptor signaling pathway (G), KEGG leukocyte trans-endothelial migration (H) and KEGG fc gamma r mediated phagocytosis (I) were enriched in the high-risk group compared with low-risk group.