Research Paper Volume 15, Issue 19 pp 10168—10192
Identification and validation of obesity related genes signature based on microenvironment phenotypes in prostate adenocarcinoma
Figure 5. Developing a ORGs signature for individual patient’s tumor microenvironment (TME) phenotypes evaluation. (A) Differences in the expression of 122 immunomodulators (chemokine, receptor, MHC and immunostimulators) between high-risk and low-risk cohorts in PRAD. (B) Correlation between ORGs signature and immune cells infiltration in TCGA-PRAD. (C) Correction between ORGs signature, JAVELIN, Tumor inflammation, IMmotion 150 T-effector response and IMmotion 150 Myeloid gene expression signatures respectively. (D) Correlation between ORGs signature, immune checkpoint (ICI) genes (topper right) and tumor inflammation signature (TIS) genes (lower left) respectively. (E) Correlation between ORGs signature and pan-cancer T cell inflamed score. (F) Heatmap of effect genes of CD8+ T cell, dendritic cell (DC), macrophage, natural killer (NK) cell and type 1 T helper (Th1) cell between high-risk and low-risk ORGs signature cohorts. (G) Correlation between ORGs signature and the individual genes included in the T cell inflamed signature.