Research Paper Volume 15, Issue 19 pp 10146—10167

Figure 6. (A) GSEA results showing differential enrichment of GO terms as a function of GPR37 expression. Top 5 GO terms for GPR37^high- positive regulation of macrophage derived foam cell differentiation, negative regulation of T cell receptor signaling pathway, leukocyte proliferation, B cell proliferation and myeloid leukocyte differentiation. Top 5 GO terms for GPR37^low- immunoglobulin complex, immunoglobulin complex circulating, antigen binding, immunoglobulin receptor binding and humoral immune response mediated by circulating immunoglobulin. (B) GSEA results showing differential enrichment of KEGG pathways as a function of GPR37. Top 5 KEGG pathways for GPR37^high-neuroactive ligand receptor interaction, calcium signaling pathway, B cell receptor signaling pathway, PPAR signaling pathway and toll like receptor signaling pathway. Two KEGG pathways in GPR37^low- ribosome, spliceosome and oxidative phosphorylation. All results of GSEA were based on NES, adjusted P value and FDR value. GSEA, gene set enrichment analysis.