Research Paper Volume 15, Issue 19 pp 10133—10145

Figure 7. Overexpression of Hmox1 counteracted the effect of SMY on DIC. (A) Hematoxylin and eosin (H&E) staining of heart tissues. (B) Sirius red staining of mice treated with DOX with or without SMY or Hmox1-OE. (C) Cardiac collagen quantification (% of collagen of area) of heart tissues. (D) Representative images of JC-1 of heart tissues. JC-1 aggregation is represented by red fluorescence and monomeric JC-1 formation by green fluorescence. (E) Histogram of aggregate JC-1/ monomeric JC-1 in mice treated with DOX with or without SMY or Hmox1-OE. The results were presented as mean ± SEM. ^*means compared with the other group, P < 0.05, ^**means compared with the other group, P < 0.01.