Research Paper Volume 15, Issue 21 pp 11697—11719

Figure 2. Behavioral tests showed cognitive and social deficits in P301S Tau mice at early time points. (A) Plots of spatial memory index in Barnes Maze tests of WT vs. P301S transgenic mice at different ages (n = WT/P301S: 1–2 m, 14/21; 3–4 m, 15/18; 5–6 m, 15/16, 9 m, 11/10). (B) Plots of discrimination index in Novel Object Recognition tests of WT vs. P301S transgenic mice at different ages (n = WT/P301S: 1–2 m, 14/21; 3–4 m, 15/17; 5–6 m, 17/9, 9 m, 11/9). (C) Plots of social preference index in 3-chamber sociability tests of WT vs. P301S transgenic mice at different ages (n = WT/Tau: 1 m, 8/10; 2 m, 13/17; 3 m, 9/13; 4 m, 7/6; 5–6 m, 9/9). (D) Plots of social novelty index in social cognition tests of WT vs. P301S transgenic mice at different ages (n = WT/Tau: 1 m, 8/10; 2 m, 14/18; 3 m, 9/13; 4 m, 7/6; 5–6 m, 9/9). ^*p < 0.05, ^**p < 0.01, and ^***p < 0.001, two-way ANOVA.