Figure 2. Construction of TRLs prognostic signature in KIRC. (A) The forest plot shows 15 prognostic TRLs using univariate Cox regression analysis. (B) The 10-fold cross-validation for the selection of optimal parameter lambda in the LASSO regression. (C) The profile of the LASSO coefficient. (D) The coefficient distributions of nine TRLs. (E) Heatmap for co-expression of signature-based TRLs and telomere-related genes.