Research Paper Volume 15, Issue 19 pp 10089—10104
Eriocitrin inhibits epithelial-mesenchymal transformation (EMT) in lung adenocarcinoma cells via triggering ferroptosis
Figure 6. Graphical abstract of the effects exerting by eriocitrin on lung cancer cells. On the one hand, eriocitrin inhibits Snail expression to impede the EMT process of lung cancer cells. On the other hand, eriocitrin prevents Nrf2 expression to inhibit antioxidative genes expression, including GPX4, SLC7A11 and FTH1, thereby to increase cellular ROS to promote ferroptosis. Besides, inhibiting ferroptosis by Fer1 inverses the inhibitory effects of eriocitrin to EMT procedure. Abbreviations: EMT: epithelial-mesenchymal transition; Fer1: Ferrostatin1.