Research Paper Volume 15, Issue 19 pp 10089—10104
Eriocitrin inhibits epithelial-mesenchymal transformation (EMT) in lung adenocarcinoma cells via triggering ferroptosis
Figure 4. Ferroptosis inhibitor Ferrostatin1 offseted the effects of eriocitrin on EMT processes of A549 and H1299 cells. (A, B) Wound healing assay showed the migration ability of A549 and H1299 cells treated with 50 μM concentration eriocitrin, Fer-1, 50 μM concentration eriocitrin and Fer-l after 24 h. (C, D) Rate of wound closure of A549 and H1299 cells after treatment with eriocitrin, Fer-1, eriocitrin and Fer-1. (E–H) Western blotting assay of EMT related protein expression after Eriocitrin treatment. *P < 0.05, **P < 0.01, and ***P < 0.001. Abbreviation: Fer-1: Ferrostatin1.