Priority Research Paper Volume 15, Issue 17 pp 8552—8575

Figure 3. Robust epigenetic differences between health and disease are clear in the 450K datasets. Distinct clustering of DNAme of healthy vs. disease cohorts. UMAP on the 450Kcytosinedataset for Arthritis, Down Syndrome, Parkinson’s Disease and BRCA1 studies (see Methods for dataset identifiers). Each point represents an individual. The clustering of healthy, cancer, and BRCA1 mutation yet no cancer cohorts is distinct for each dataset.