Figure 8.Signaling pathways for tumorigenesis effects by NOTCH2 mutation. Apoptosis effects through the pAKT-Bax/Bcl-2 and pNF-κB/Rel pathways. Meanwhile, NOTCH2 mutation promoted tumor cell migration, invasion, and proliferation through Hes 1 and TAMs involved in the tumor microenvironment (TME). Abbreviations: NICD: Notch2 intracellular domain; TAMs: tumor-associated macrophages.
