Research Paper Volume 15, Issue 20 pp 10996—11011

BTN2A2, a new biomarker and therapeutic target for glioma

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Figure 9. Knockdown of BTN2A2 expression inhibits the proliferation and migration of glioma cells. (A) IHC shows BTN2A2 expression in glioma and normal brain tissues. (B, C) The efficacy of BTN2A2 knockdown in SF295 and LN229 using qRT-PCR. (D, E) BTN2A2 knockdown inhibits the growth of SF295 and LN229 cells determined using growth curve. (F, G) BTN2A2 knockdown inhibits the migration of SF295 and LN229 cells determined using the colony information assay. (H, I) BTN2A2 knockdown inhibits the migration of SF295 and LN229 cells determined using the transwell assay. Scale bar = 250 um. Abbreviations: NC: Negative control; siRNA: Knockdown of BTN2A2. *P < 0.05, **P < 0.01, ***P < 0.001.