Research Paper Volume 15, Issue 24 pp 14607—14616
The protective effects of Phoenixin-20 in tumor necrosis factor α (TNF-α)-induced cell senescence of rheumatoid arthritis fibroblast-like synoviocytes (FLS)
Figure 6. Phoenixin-20 downregulated p53 and p21 in TNF-α-treated RA-FLSs. RA-FLSs were stimulated with TNF-α (10 ng/mL) with or without Phoenixin-20 (10, 20 nM) for 7 days. (A) mRNA of p53 and p21; (B) Protein of p53 and p21 (※P < 0.01 vs. vehicle group; #, ##, P < 0.05, 0.01 vs. TNF-α group, N = 5–6).