Figure 4.Immunohistochemistry shows aspirin suppress DSM tissue inflammation in diabetic rats after 10 weeks administration. (A) Immunohistochemistry indicates the expression of inflammatory mediators IL-6, IL-1β, TNF-α, and NF-κB was mainly distributed in the mucosa, lamina propria and meanwhile detrusor muscle. Arrows indicate positive staining (brownish-yellow). (B) The average optical density of IL-6, IL-1β, TNF-α, and NF-κB were analyzed using Image J Analysis System. Data were presented as mean±SD. N=6. (***, P < 0.001; NC vs DCP; DCP vs DCP+Aspirin).
