Research Paper Volume 15, Issue 17 pp 9128—9143

Figure 4. Immunohistochemistry shows aspirin suppress DSM tissue inflammation in diabetic rats after 10 weeks administration. (A) Immunohistochemistry indicates the expression of inflammatory mediators IL-6, IL-1β, TNF-α, and NF-κB was mainly distributed in the mucosa, lamina propria and meanwhile detrusor muscle. Arrows indicate positive staining (brownish-yellow). (B) The average optical density of IL-6, IL-1β, TNF-α, and NF-κB were analyzed using Image J Analysis System. Data were presented as mean±SD. N=6. (***, P < 0.001; NC vs DCP; DCP vs DCP+Aspirin).