Figure 4. Heatmaps and volcano plots of differentially expressed genes in brain tissue after latent herpesvirus infection. Heatmaps and volcano plots of differentially expressed genes in the brain tissue after infection with wild-type herpes simplex virus (HSV)-1 (A, B) and mutant HSV-1 (C, D) are shown. In the volcano plots, red dots represent genes with high differential expression, cyan dots represent genes with low differential expression, and black dots represent genes with no differential expression. The MOCK group had a sample size of n = 3, the MHV-68 group had n = 3, and the ORF73 group had n = 3.