Research Paper Volume 15, Issue 17 pp 8908—8929
TIMP1 shapes an immunosuppressive microenvironment by regulating anoikis to promote the progression of clear cell renal cell carcinoma
Figure 1. Establishment and validation of anoikis-related clusters. (A) Screening of 48 ARGs associated with prognosis and differentially expressed; (B) Heatmap plot indicating the consensus matrix of NMF clustering results utilizing the gene expression profile in TCGA KIRC cohort, colored by two ccRCC clusters; (C) KM survival curves revealing the prognosis difference of the two clusters (A1, A2); (D) The distribution of anoikis-related genes expression profile and clinicopathological characteristics in A1 and A2 clusters; (E) The results of GO biological process enrichment of differentially expressed genes; (F) The results of KEGG pathways analysis of differentially expressed genes; (G) Results of GSVA enrichment analysis between clusters; (H) Heatmap plot indicating the consensus matrix of NMF clustering results utilizing the gene expression profile in the E-MTAB-1980 cohort, colored by two ccRCC clusters; (I) KM survival curves revealing the prognosis difference of the two clusters (A1, A2).