Research Paper Volume 15, Issue 17 pp 8812—8832
SUMO1-regulated DBC1 promotes p53-dependent stress-induced apoptosis of lens epithelial cells
Figure 11. Model for the role of DBC1 in p53-dependent stress-induced apoptosis. DBC1 can be SUMOylated at K591 by SUMO1 conjugation in lens epithelial cells. Upon oxidative stress, DBC1 inhibits p53 phosphorylation (derived from upstream kinases such as CHK1/2, JNK1/2 and ERK1/2 depending on the stimuli) to modulate p53 functional status. DBC1 SUMOylation enhances p53-depedent oxidative stress-induced apoptosis, which eventually causes cataractogenesis.