Figure 6. Experimental validation of hub genes. (A–D) MNDA, TNC, CHIT1 and MMP9 were found to be highly expressed in patients’ serum with obesity combined with PTC ((A) P < 0.01, (B) P < 0.05, (C) P < 0.01, (D) P < 0.001). (E–I) The expression of four hub genes in the patient tissues and the normal tissues (F) patient1: P < 0.01, patient2: P < 0.01, patient3: P < 0.01; (G) patient1: P < 0.01, patient2: P < 0.05, patient3: P < 0.05; (H) patient1: P < 0.01, patient2: P < 0.01, patient3: P < 0.05; (I) patient1: P < 0.01, patient2: P < 0.01, patient3: P < 0.05). P < 0.001 was denoted as “***”, P < 0.01 as “**”, P < 0.05 as “*”, and P > 0.05 as “ns”.