Research Paper Volume 15, Issue 16 pp 8471—8486

Tumor-derived exosomes RNA expression profiling identifies the prognosis, immune characteristics, and treatment in HR+/HER2-breast cancer

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Figure 4. Exploration of the exosome score predictive role in the TCGA cohort. (A) Raincloud Plot shows the comparison of ES between the different immune subtypes. (B) Lollipop plot showing the comparison of immune-related features between the low- and high-score groups. The length of the stick represents the difference between the medians of the features in the high- and low-score groups. (C) Circos Plot displays the CNVs distribution in ES-relevant groups, and red dots represent the difference between the incidence of CNVs in the high- and low-score groups. (D) Violin plot showing the distribution of the two groups in different immune cells, NA p > 0.05, * p < 0.05, ** p < 0.01, *** p < 0.001. ES, exosome score; TCGA, The Cancer Genome Atlas; CNVs, copy number variations; aDC, activated dendritic cells; CD8+ T, CD8 T cells; iDC, immature dendritic cells; NKbright, NK CD56 bright cells; NKdim, NK CD56 dim cells; Tcm, central memory T cells; Tem, effector memory T cells; Tfh, follicular helper T cells; Tgd, gamma delta T cells; Th, helper T cells; Treg, regulatory T cells.