miR-100-5p activation of the autophagy response through inhibiting the mTOR pathway and suppression of cerebral infarction progression in mice

Xiaoyun Cao; Xiangjian Zhang; Junmin Chen; Qian Sun; Yufan Sun; Na Lin; Xiaoxia Liu

doi:doi:10.18632/aging.204971

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Research Paper Volume 15, Issue 16 pp 8315—8324

miR-100-5p activation of the autophagy response through inhibiting the mTOR pathway and suppression of cerebral infarction progression in mice

Figure 1. The bioinformatics analysis results of GSE102541 and GSE86291. (A, B) The DEGs of GSE102541 are presented in the volcano plots and cluster analysis diagrams. (C, D) The volcano plots of GSE86291 (the downregulated DEGs included miR-100) and cluster analysis diagrams. The Venn diagram (E) predicted using miRDB, starBase, and TargetScan, shows the intersection of miRNAs targeted mTOR, and the shared miRNA (miR-100-5p) with GSE86291. (F) The binding sites between miR-100-5p and mTOR. (G, H) The expression of mTOR and miR-100-5p in CI and the control tissue of GSE102541. (I, J) The GO enrichment analysis charts and GO chord graphs of GSE102541. (K, L) The GO enrichment analysis charts and GO chord graphs of downregulated genes in GSE102541. (M, N) The KEGG enrichment analysis charts and GSEA chart of GSE102541. DEG, differentially expressed gene; miRNA, microRNA; CI, cerebral infarction; GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes; GSEA, gene set enrichment analysis; mTOR, mammalian target of the rapamycin.