Research Paper Volume 15, Issue 16 pp 8298—8314
Gastrodin ameliorates cognitive dysfunction in diabetes by inhibiting PAK2 phosphorylation
Figure 3. Gastrodin intervention suppressed diabetes induced PAK2 phosphorylation and activated PI3K/AKT/GLUT4 pathway. Western blot analysis of p-PAK2 (A) PI3K (B) p-AKT (C) and GLUT4 (D) protein expression in the hippocampus of the NC9W, DM9W+S, DM9W+G60 and DM9W+G120 groups. Bar graphs represented optical density of these factors normalized with β-actin, while p-PAK2 and p-AKT were further normalized with total-PAK2 and total-AKT respectively. *p < 0.05 and **p < 0.01.