Research Paper Volume 15, Issue 16 pp 8220—8236

Figure 5. VCP20 impedes MM cell proliferation and prolongs MM mice survival in vivo. (A) Photographic images of xenograft mice at Day 31 (n = 4, VCP20: i.p. 20 mg/kg, twice a week). (B) Images of the harvested xenograft tumors. (C) Mean tumor weight of NOD/SCID mice. (D) Time course of tumor growth. V = 0.52 × larger diameter × (smaller diameter)². (E) Representative micro-CT images of the bones. (F) BMD of 5TMM3VT mice in Control and VCP20 groups. (G) BV/TV of 5TMM3VT mice in Control and VCP20 groups. (H) VCP20 treatment started from the day after injection (VCP20: i.p. 20 mg/kg, twice a week) and continued until the mice were dead. (I) VCP20 extended the survival period of MM mice (n = 8). Data are presented as the mean ± SD; *p < 0.05; **p < 0.01.