Research Paper Volume 15, Issue 16 pp 8113—8136

Figure 1. Comprehensive characterization of genetic and expression alterations of pyroptosis-related genes in gastric cancer. (A) Circos 2D track plots showing the location of 33 pyroptosis-related genes on chromosomes. (B) The mRNA expression of 33 pyroptosis-relevant genes in 32 normal and 375 gastric cancer tissue specimens from TCGA-STAD cohort. The asterisks indicated the statistical p-values (^*p < 0.05; ^**p < 0.01; ^***p < 0.001) and ns indicated no statistical significance. (C) The somatic mutation frequency of 33 pyroptosis-relevant genes in 433 gastric cancer samples in TCGA-STAD dataset. The upper barplot displayed somatic mutation. The stacked barplot exhibited the fractions of conversions of specimens. The number on the right showed the mutation frequency in each pyroptosis-related gene. The right barplot showed the proportion of each mutation type. (D) Summary of the CNV frequency of 33 pyroptosis-related genes. The column height indicated the mutation frequency. Amplification, red; deletion, blue. (E) The PPI network visualizing the interactions between 33 pyroptosis-relevant genes.