Research Paper Volume 15, Issue 16 pp 8090—8112
Identification of immunotherapy biomarkers for improving the clinical outcome of homologous recombination deficiency patients with lung adenocarcinoma
Figure 2. HRD scores were significantly associated with prognosis and mutation characteristics in the TCGA-LUAD cohort. (A) KM curve of overall survival of patients with HRD or non-HRD tumors in the TCGA-OSC cohort. (B) ROC curves of HRD scores in the TCGA-LUAD cohort. (C) Violin plots of somatic mutations in the HRD and non-HRD groups. Somatic mutation counts were significantly higher in the HRD group than in the non-HRD group. (D) Violin plots of MSI-Sensor in HRD and non-HRD groups. MSI-Sensor in the HRD group were significantly higher than those in the non-HRD group. (E) Violin plots of genomic alterations in the HRD group and non-HRD group. *P < 0.05, **P < 0.01, ***P < 0.001.