Research Paper Volume 15, Issue 16 pp 8061—8089

Figure 1. LM-021 and NC009-1. (A) Structure and formula of LM-021 and NC009-1. (B) Molecular weight (MW), hydrogen bond donor (HBD), hydrogen bond acceptor (HBA), calculated partition coefficient of octanol/water (cLogP), polar surface area (PSA), and blood–brain barrier (BBB) permeation score of LM-021 and NC009-1. (C) DPPH free radical scavenging activity of kaempferol (as a positive control), LM-021 and NC009-1 (10−160 μM) (n = 3). Shown below are the EC₅₀ values. (D) Trolox equivalent oxygen radical antioxidant capacity of LM-021 and NC009-1 (5−20 μM) (n = 3). (E) Cytotoxicity of LM-021 and NC009-1 against mouse BV-2 and human BE(2)-M17 cells determined by using the MTT assay. Cells were treated with each test compound (0.1–100 μM) and cell viability was analyzed the next day (n = 3). For normalization, the relative viability of untreated cells was set at 100%.