Research Paper Volume 15, Issue 15 pp 7616—7636

Figure 4. Independent prognostic analysis of ARL. (A) Univariate Cox regression analysis shows the correlation between OS rate and clinicopathological parameters, including age, stage, T stage, N stage, and the ARL prognostic signature risk score. (B) Multivariate Cox regression analysis shows that age, stage, and risk score are independent prognostic predictors of patients with breast cancer. (C) Receiver operating characteristic curve (ROC) shows the areas under the curve (AUC) of the prognostic signature and clinical characteristics. (D, E) Nomogram construction of the prognostic signature and clinicopathological parameters to predict the 1-, 3- and 5-year survival rates of patients with breast cancer. Time-dependent ROC curve shows the 1-, 3-, and 5-year AUC. (F) Calibration curve reveals the accuracy between predictive power and actual survival of 1-, 3-, and 5-year survival.